Windows 8 upgrade diary: a defiantly successful installation

Nothing's nicer than a happy ending. Except maybe a happy beginning, which is precisely what you're looking at above -- Microsoft's new OS captured in all its glory within minutes of completing the installation. What's more, if you saw the first part of this upgrade diary, then you'll know I was aiming for a trickier-than-average setup, with Windows 8 Pro running on a brand new and untouched SSD, alongside Windows 7 Ultimate running in dual-boot mode on my old HDD. As it turned out, this configuration was a breeze -- so long as I totally ignored the Getting Started instructions that came in the box. Read on if you'd like to know more.

Continue reading Windows 8 upgrade diary: a defiantly successful installation

Filed under: Desktops

Windows 8 upgrade diary: a defiantly successful installation originally appeared on Engadget on Mon, 29 Oct 2012 18:20:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/KbG5DN8oxkE/

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Google reveals Nexus 4, Nexus 10 ... and more Nexus 7

14 hrs.

Rosa Golijan , NBC News

Google may have canceled the Android event which was scheduled for 7 a.m. PT/10 a.m. ET on Monday morning because of Hurricane Sandy, but that doesn't mean we're being deprived of gadget news. The Mountain View, Calif. company has announced a new LG-made?Nexus smartphone and a 10-inch tablet by Samsung.

As expected, thanks to rumors and leaks, the new Nexus smartphone is dubbed the Nexus 4. It?has a 4.7-inch screen with a "retina"-dense?320 pixels per inch which rivals the 326 ppi found on recent iPhones.?The phone has a powerful?quad-core processor, and will run Android 4.2. (This is still nicknamed Jelly Bean, in case you were tracking those silly things.) It will be available in an 8GB version for $299 and a 16GB version for $349. You can snag it as early as Nov. 13, unlocked and without contract. If you don't mind signing a two-year service agreement, then you can get a 16GB version from T-Mobile for $199.

What Google hasn't mentioned is whether or not there will be an LTE version of the Nexus 4, or?one that would?runs on carriers such as Verizon Wireless or Sprint, which don't support the announced specs. All the models listed are GSM/HSPA+, meaning in the U.S., they'll only run on AT&T and T-Mobile. Hopefully a phone supporting CDMA and LTE will be released in the coming months, so we'll keep asking.

The new Nexus 10 tablet also doesn't come as a surprise to those who have been paying attention to the rumor mill.?The device is a larger version of the popular Nexus 7 tablet. The?Samsung device offers a high-resolution 2560 x 1600 display (that translates to 300 ppi ? more dense than the latest iPad's?264 ppi).?According to Google, the Nexus 10 can handle up to nine hours of video playback and more than 500 hours of standby time on a single charge. ?Like the Nexus 4, it will ship with Android 4.2.?You can snag a 16GB version of the Nexus 10 for $399 and a 32GB version for $499. It will be available through the Google Play Store on Nov. 13.

But wait! There's more! Google also decided to offer up several more Nexus 7 models as well. The smaller tablet will now be available in a 16GB version and 32GB version, priced at $199 and $249, respectively. An additional 32GB model with HSPA+ connectivity will be offered through AT&T for $299, starting on Nov. 13.

Want more tech news?or interesting?links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.

Source: http://www.nbcnews.com/technology/gadgetbox/google-reveals-nexus-4-nexus-10-more-nexus-7-1B6737539

Kara Alongi Sahara Davenport Resident Evil 6

Energy markets rise on Sandy, insurers fall

NEW YORK (Reuters) - U.S. gasoline and heating oil futures gained while U.S. Treasuries also rose on Monday, as economic worries over Hurricane Sandy fuelled safe-haven buying in thin trading as the powerful storm began to batter the U.S. East Coast.

The storm closed Wall Street on the anniversary of the 1929 stock market crash. It was the stock market's first weather-related closure in 27 years, and other markets closed early as investors braced for the impact of Sandy, one of the biggest storms ever to slam the U.S. eastern seaboard.

U.S. stock and bond markets will be closed on Tuesday, but the two-largest U.S. stock exchange operators, NYSE Euronext and Nasdaq OMX Group, intend to reopen Wednesday, conditions permitting.

Trading was thin in U.S. foreign exchange, fixed income, precious metals and energy markets as public transportation was shut in New York and parts of lower Manhattan were evacuated.

"You have uncertainties now. You have these safe haven purchases. People are trying to figure out the economic impact from the storm," said Larry Milstein, head of government and agency trading at R.W. Pressprich & Co in New York.

"Right now it's the easy way to buy Treasuries and wait to see what happens," Milstein said.

Benchmark U.S. 10-year Treasury notes traded 8/32 higher in price to yield 1.7206 percent.

U.S. heating oil futures gained, touching the highest level relative to U.S. crude oil on record, as dealers hedged against the risk of power outages and flooding from Sandy that could damage refineries and keep production shut for weeks.

The crack spread, the difference in value between a barrel heating oil and a barrel of crude oil, touched $45.15 a barrel.

"Markets will be watching for reports of damage to energy infrastructure, notably refineries, post-Sandy, given the state of extremely low gasoil inventories as we move into winter season," Deutsche Bank analysts said.

Gasoline futures reached $2.8115 a gallon, the highest since October 17, before paring gains as traders factored in the reduced demand for fuel with the almost total shut-down of eastern seaboard roads and airports.

In Europe stocks, led by insurers, fell on expectations Sandy-related damage will boost claims, while political jitters in debt-laden Italy cast shadows on the euro zone.

Reinsurers Swiss Re and Hannover RE led a weaker European insurance sector index as the market tried to foresee the clean-up costs of Sandy.

"We are seeing insurers slide and we've sold a bit of Aviva and RSA," said Ed Woolfitt, head of trading at Galvan Research.

Euro zone blue chips shed 0.7 percent to 2,478.84 points after former Prime Minister Silvio Berlusconi threatened to bring down the government of his successor, Mario Monti, which has appeased markets with its austerity agenda.

The broader MSCI world equity index lost 0.26 percent to 327.74 points - on track for its worst monthly performance since May as doubts grow over the effect of the latest round of central bank efforts to boost activity.

The euro fell against the dollar and yen, hurt by uncertainty over whether Greece can agree to a deal on austerity and with no sign of when Spain might request aid.

The single currency was expected to stay subdued against the dollar and the yen, with investors preferring safe-haven currencies on renewed worries about weak earnings from top companies in the region.

The single currency was down 0.3 percent at $1.2898, not far from a two-week low of $1.2881.

The dollar rose to a session high against the yen ahead of a Bank of Japan policy review on Tuesday at which the central bank is expected to further ease monetary policy.

The dollar was last up 0.2 percent at 79.80, the session peak.

U.S. consumer spending rose solidly in September, putting the economy on a firmer footing heading into the fourth quarter even though households had to pull back on saving to fund purchases.

But the rise in consumer spending will mask a pullback late in the year as businesses hold investments in anticipation of higher taxes and cuts in federal spending that will kick in beginning early next year if Congress doesn't act, said Ellen Zentner, senior U.S. economist at Nomura Securities in New York.

Positive surprises, including third-quarter U.S. growth data and signs of stabilization in China, have failed to persuade investors that the world economy can achieve lasting growth as multinational global companies have forecast weak revenues.

(Reporting by Herbert Lash; Editing by David Gregorio and Steve Orlofsky)

Source: http://news.yahoo.com/asian-shares-edge-higher-u-growth-002856800--finance.html

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Business Travel Stress, Defined | Gadling.com

Business travel stress is caused by a number of reasons. Just being out of the office can make communication and keeping up with ongoing projects a challenge. Some travelers cope well with the challenges of working on the road. Others, not so much. A recent survey by Carlson Wagonlit Travel (CWT) polled more than 6,000 frequent business travelers from nine global corporations, and found that stress tends to fall into three categories.

Time lost when a traveler might be working but instead has to stand in a security line can add stress. Thinking "If I was in the office right now, I could be doing something productive" adds more stress.

Surprises caused by an unscheduled event that disrupts travel is another. Major storms with a cascading effect on airports not even in the affected area commonly add "Will I make my connection?" stress.

Routine breakers that cause an inability to stick to regularly scheduled home activities count too. Activities that are easy to do at home like exercising, watching television or surfing the web add stress when not done on the road.

The biggest stress factor of all? Lost Luggage.

"Losing one's baggage requires replacing the lost content, often in a short space of time. This presents multiple uncertainties under tight deadlines, which produced considerable stress," Carlson Wagonlit Travel (CWT) said in an Executive Travel article.

Coming in at number two on the list of 33 possible stress triggers was being without an Internet connection, or having an unreliable one. Third place was having to fly in coach on a medium or long-haul trip, followed by flight delays, inconvenient arrival or departure times, having to stay in a low-category hotel, inconvenient hotel locations, and last-minute travel.

[Photo Credit: Flickr user Samuel R?nnqvist]

Filed under: Business, North America, United States

Source: http://www.gadling.com/2012/10/29/business-travel-stress-defined/

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Nokia Lumia 822 and HTC 8X show up in Verizon colors, get pegged for November 8th release

The Verizon-flavored Nokia Lumia 822 hasn't exactly been camera-shy, nor has it been coy about its imminent arrival, but the details on price and availability have, as yet, not been pinned down. That is until now, according to a tip-off at WPCentral. The candid shot shows the Nokia next to an HTC 8X -- both with Verizon livery. The word is that the Lumia 822 will run you $99 at launch, while the HTC 8X will command $199, both with a contract. The same source claims that these will launch on November 8th. Just in time to get that first killer app.

Update: Not satisfied with just white? Don't worry about it -- you'll have two more shades to pick from, according to a press image uncovered by EvLeaks. A professionally captured view of the 822's black and grey facades can be found at the more coverage link below.

Filed under: Cellphones, Mobile, HTC, Nokia, Verizon

Nokia Lumia 822 and HTC 8X show up in Verizon colors, get pegged for November 8th release originally appeared on Engadget on Sun, 28 Oct 2012 01:03:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/10/28/nokia-lumia-822-and-htc-8x-in-verizon-colors/

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Heathrow warns weak summer traffic to hit earnings

LONDON (Reuters) - Heathrow Ltd, formerly known as BAA, warned full-year earnings would fall short of its target, after fewer passengers travelled through Europe's busiest airport this summer.

"Traffic over the summer months was lower than expected, particularly in July and August when passenger traffic was down about 400,000 on the same period in 2011," chief financial officer Jos? Leo said on Monday, referring to London's Heathrow airport.

In June, the group predicted it would report adjusted earnings before interest, taxes, depreciation, and amortisation (EBITDA) of around 1.27 billion pounds for 2012.

Heathrow said its EBITDA rose 9.6 percent to 922.9 million pounds in the nine months to the end of September on revenue 8.2 percent higher at 1.84 billion pounds, helped by an increase in tariffs it charges airlines.

The company, owned by Spanish infrastructure group Ferrovial, said Heathrow, Europe's busiest airport, handled 53 million passengers in the first nine months of 2012, up 0.6 percent on last year.

However, traffic at London Stansted, which is predominantly a low-cost leisure and holiday airport and more exposed to domestic economic conditions, fell 4.6 percent to 13.5 million in the same period.

The operator said the sale of Stansted, which handled 18 million passengers last year, was now underway after Britain's competition regulator forced it to sell the airport to loosen the group's grip on the UK.

"The sale of Stansted will take a matter of months," said Leo, who added that it would "probably be next year" before a deal was completed.

Single runway Stansted is based 50 kilometres northeast of central London and is the fourth-busiest airport in the UK.

Manchester Airports Group, Macquarie, J.P. Morgan Asset Management and Morgan Stanley Infrastructure are expected to bid for Stansted, according to sources.

Plans for extra runways at Stansted and Heathrow were dropped by BAA after the Conservative-Liberal Democrat coalition came to power in 2010 and the future of the airports is unclear.

Leo dismissed the idea of connecting Heathrow and Stansted with the Crossrail line that will run between east and west London to create a 'dual hub' as a way to solve the air capacity crunch in London and the south east of England.

Hub airports are used as a transfer point where passengers can easily change planes to travel on to another destination.

"Airlines won't operate a dual hub easily because the transfer time will be too long, killing the competitive advantage a hub airport has," he said.

Heathrow Ltd also owns Southampton airport in southern England and Glasgow and Aberdeen airports in Scotland.

(Editing by Erica Billingham)

Source: http://news.yahoo.com/heathrow-nine-month-earnings-9-6-percent-073449434--finance.html

madmen james cameron

Web Traffic Tips: The Top Place To Get The Best FREE Traffic Online

In today?s post we are taking about TRAFFIC! We talk a lot about traffic on this blog?how to drive traffic, where to find traffic and other web traffic tips that help you boost leads and increase sales. But one of the most common questions I get from students and clients is ?Where are the top places to get the best FREE traffic online?? So I am going to share with you just that?and the web traffic tips I give you may come as a surprise.

Let?s get started?.

As an online marketer I am going to assume you are promoting and marketing some product?whether it is your own signature products, an affiliate program or online business opportunity.? Whatever it is that you are promoting, to make money, you must get the best FREE traffic (buying traffic) in front of your offer. Buying traffic is what I like to call ?hot traffic? ? people who are actively searching Google for solutions and are ready to buy if they find what they believe to be the answer to their problem.

There are two types of blog traffic you can tap into:

1. Paid Web Traffic: Traffic that is reliable, higher quality and often more scalable
2. Free Blog Traffic: Cheaper, less reliable but comes with less risk

When it comes to getting the best FREE traffic ? I have found that FORUMS are some of the very best places to attract quality, ready to buy, engaged leads and prospects. While you may not get a traffic swarm from forum marketing, you will get higher converting traffic.

Tracking Your Links

One of the reasons I know forums provide the best free traffic online and are a great source for high quality blog traffic is because I track my activity. It is very important to collect data and be knowledgeable about what is working for you and what is not. This way you are using your time and marketing efforts efficiently and effectively by only focusing on the highest income producing activities.

The only way to pinpoint exactly where your leads and sales are coming from is to track, track, track.

I use trackable links using bit.ly, ninja affiliate and the google url builder.

?

So when you are creating your signature profiles in various niche related forums you will always want to make sure you are using a trackable link so you will always be able to see the volume of traffic coming from any one particular site and know how that traffic converts.

Volume of Forum Traffic

Now I want to make one thing clear, forum marketing is not going to drive tons and tons of ?free blog traffic? to your sites and landing pages, however it will drive the ?best FREE traffic? you can get online, providing you a more quality lead. The quality of forum traffic is hugely better than any other type of free blog traffic you can employ as part of your overall online marketing strategy.

So if I use a trackable link in my forum signature profile and I post something on the warrior forum, a forum member can read my post, click the link in my signature that leads them to some sort of freebie. Because my link is trackable I can see exactly how many people click the link and then opt in. I can then compare the number of leads hat convert into sales to the same offer I promote on Facebook, or Twitter or even in a blog post.

While I can get a lot of volume on social sites like Facebook and Twitter the conversions from clicks to opt-ins and opt-ins to buys are typically 50% less than equal traffic generated from forums.

So if you are looking for the best FREE traffic, find niche related forums and begin posting on those forums, making sure you have a compelling signature line. I ever market where do the most passionate people go?

They are hanging out in forums?they are actively engaging, discussing and seeking information that can help them. Just think of parents forums, stay at home mom forums, make money online forums?these forums are buzzing with people who are excited, motivated and passionate about their particular topic and they are trying to figure out everything little bit of information that can help them achieve whatever it is they are looking for.

What To Avoid

While forums are awesome for attracting some of the best free traffic you can get online, it can also we a time snatcher. It is very easy to get sucked into forums, searching for threads to comment on, answering questions and going back and forth with other members. So be very careful how you spend your time in forums. Commit to 30 minutes to an hour each day then shut it down!

Also forums can be a breeding ground for conflict, combativeness and negativity. So be careful of how you let comments and responses affect your mindset.

So if you?re looking for the best free traffic, want quality web traffic, then make sure forum marketing is a regular and consistent part of your money making marketing methods. Make sure you are participating and making your presence known by contributing good value?not by spamming your links. Give good advice and good answers, make sure you test different signature files and optimize the copy for the best click through rates.

For more free web traffic tips and information on the best places to get FREE blog traffic online. Click here for more >>

Source: http://andreabolder.com/2012/best-free-traffic/

san jose sharks

Google's Android event: 'Nexus 4,' 'Nexus 10' and more Nexus

7 hrs.

Rosa Golijan , NBC News

Google's got an Android?event scheduled for Oct. 29, about a year following the announcement of the Galaxy Nexus smartphone and Android 4.0 (better known as Ice Cream Sandwich). As with every event of this magnitude, there's a host of rumors about what might be announced. Here are the best ones:

Nexus 4
Based on photos posted to Google+ by LG and Google employees, the next Google Nexus smartphone will be made by LG and called the Nexus 4.?Given that the Nexus 7 is a 7-inch tablet, we could assume that the Nexus 4 will be a 4-inch device.

The Next Web's Matt Brian says that a "source with knowledge of Google's plans" claims that the Nexus 4 will have a quad-core 1.5 GHz ?processor, 2GB RAM, 16GB storage, an 8-megapixel rear-facing camera (and 1.3-megapixel front-facing camera). According to this individual, the device will have a?a?4.7-inch display with a?1280 x 768 pixel resolution. (If that's the case, we wonder why Google didn't round up and dub the device the Nexus 5.)

Like prior Nexus devices, the Nexus 4 is expected to be among the first to run Google's latest and greatest mobile operating system, Android 4.2.

Nexus 7
The Nexus 7 has been around since late June, after being announced during Google I/O, and Google's giving it extra attention nonetheless. According to multiple reports, the tablet will now come in two 32GB versions, ?one of which will offer HSPA+ connectivity.?

Nexus 10
Google and Samsung have been working together on a 10-inch tablet, writes the Next Web's Matt Brian. This tablet will supposedly be dubbed the Nexus 10 and offer a higher resolution display than the third-generation iPad, as previously suggested by analysts.

Android 4.2
Google is expected to show off Android 4.2 during the Oct. 29 event and, according to the Next Web's Matt?Brian, this latest version of Google's mobile operating system is expected to compete directly with Apple's iOS 6 (though that's pretty much a given). Brian's mystery source says that Android 4.2 will offer new panoramic camera features, a way to access Play Store content from a widget, and multi-user support for tablets.

Want more tech news?or interesting?links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.

Source: http://www.nbcnews.com/technology/technolog/googles-oct-29-android-event-nexus-4-nexus-10-still-1C6612162

cleveland news

Why You Need a Michigan Car Accident Lawyer | attorneys at ...

Why You Need a Michigan Car Accident Lawyer

To protect your legal rights, talk with our Michigan car accident lawyerslawyers if you are hurt in an auto accident.

Since 1968, our law firm has championed the rights of accident victims. TheBernstein Advantage has helped over 100,000 clients recover over $500 million in damages.
After a serious auto accident, it is important to talk with a Michigan personal injury attorney with experience in Michigan auto accident law for several compelling reasons:

Put a Fighter In Your Corner

Insurance companies will vigorously fight against paying damages to an injury victim -- especially cases involving an auto accident. Our Michigan personal injury law firm will vigorously represent your interests in these proceedings and counsel you as your claim progresses. At the same time, we will do everything possible to ensure the emotional well being of you and your family as we pursue your Michigan car accident claim

.

Peace of Mind

You owe it to yourself and your family to seek experienced legal counsel. If ourMichigan car accident law firm law firm pursues a claim on your behalf, you can be assured that professional legal counsel is working to obtain all relevant medical records, reviewing all documentation, and consulting with leading experts to maximize the value of your personal injury claim.

Professional Evaluation of Your Claim

Our Michigan car accident lawyers will diligently gather all of the documentation, make a determination, and file the appropriate claim on your behalf. We will advise you on the range of value of your claim, and the best way to proceed.
To protect all your legal rights, you need a Michigan auto accident law firm that is well versed in the complicated laws that govern Michigan auto accident law.

The Financial Impact of Injuries

The cost of a serious injury suffered in an auto accident can be catastrophic. This is an extreme hardship when the injuries make work impossible and rent, gas, and medical bills start to accumulate. Our law firm will help you recover these costs from the insurance company or the at-fault party.

Maximize the Value of Your Claim

To protect all your legal rights, you need a Michigan law firm that is well versed in the complicated Michigan laws that cover auto accident legal claims. A study recently indicated that injured parties represented by legal counsel obtain far greater recoveries than those individuals who attempt to represent their own interests.

If you or a loved one suffered a serious injury in an auto accident, talk with an experienced Michigan auto accident lawyer today. Please submit a simple, free, and confidential legal consultation form now.

Protect your rights. Get the Bernstein Advantage today.

video_iconVideo: Michigan car accident attorney Sam Bernstein explains how theBernstein Advantage can help Michigan car accident victims.

For more information about your legal rights after a Michigan car accident, visit our special website, www.michigan-auto-accident.com, dedicated to helping Michigan auto injury victims.

Source: http://attorneys-at-michigan.blogspot.com/2012/10/why-you-need-michigan-car-accident_21.html

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Why It Matters: Abortion & Birth Control | NBC17.com

By: Associated Press | NBC-17
Published: October 16, 2012 Updated: October 16, 2012 - 11:16 PM

The issue:

Whether women have access to abortion services and birth control is a long-standing and divisive issue in politics, and it has flared up from time to time in this campaign despite the candidates' reticence to dwell on such hot-button topics.

Where they stand:

President Barack Obama supports access to abortion. His health care law requires contraceptives to be available for free for women enrolled in workplace health plans.

Republican Mitt Romney favors limits on abortion, though he previously supported access to it. He says Roe v. Wade, the Supreme Court ruling establishing abortion rights, should be reversed, which would allow states to ban abortion. He would end federal aid to Planned Parenthood, a major provider of abortion and contraception, and has criticized mandatory coverage for contraception as a threat to religious liberty when it's applied to employers, such as Catholic hospitals, that disagree.

Why it matters:

There's been a lot of heated talk this year by Democrats contending that Republicans are waging a "war on women." That's hyperbole, retorts the GOP, but there are indeed stark differences between the two parties over these volatile issues.

Obama's Affordable Care Act, which Republicans opposed and want to repeal, vastly expands women's access to copay-free preventive health care, including contraception.

The U.S. Conference of Catholic Bishops and many conservative Protestant evangelicals have denounced this contraception mandate, saying it violates religious freedom. The provision generally exempts houses of worship, but faith-affiliated employers would have to comply.

Obama's campaign has been running ads aimed at female voters, noting that Romney supports overturning Roe v. Wade and has assailed the contraception coverage requirement as a "war on religion."

Were Romney to be elected, his ability to push through tough federal abortion restrictions would probably be limited unless Republicans gained firm control of both chambers of Congress.

However, the next president ? Obama or Romney ? could have huge influence over the future of abortion policy if vacancies arise on the Supreme Court. For example, if two seats held by liberal justices were vacated and filled by Romney-nominated conservatives, prospects for a reversal of Roe v. Wade would increase.

"That's bigger than everything else combined, because of the long-term consequences," said anti-abortion rights activist Charmaine Yoest, president of Americans United for Life.

Another issue of contention is the federally financed family planning program known as Title X. Romney has proposed ending the program, as well as all other federal money for Planned Parenthood. Obama supporters say this could be harmful to the large numbers of women who rely on Planned Parenthood clinics for affordable birth control, breast-cancer screenings and other services.

Aside from the presidential and congressional elections, there's a lot riding on the results of state-level elections. Anti-abortion rights activists hope for further gains to accelerate a dramatic trend of the past decade: the enactment of scores of laws restricting access to abortion in states with Republican-controlled legislatures.

Among these measures are laws in several states prohibiting abortion after 20 weeks of pregnancy, on the disputed premise that fetuses can feel pain at that stage; and a South Dakota law requiring doctors to warn women seeking abortions that they face increased risk of suicide by undergoing the procedure. In Mississippi, the lone abortion clinic is threatened with closure because of a new law requiring abortion providers to have hospital admitting privileges.

In some parts of the country, abortion providers already are so scarce that women with an unintended pregnancy face a choice between reluctantly bearing a child or traveling hundreds of miles for an abortion. Election results could reduce access even further in some states.

Source: http://www2.nbc17.com/news/2012/oct/16/why-it-matters-abortion-birth-control-ar-2700085/

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Cold viruses point the way to new cancer therapies

ScienceDaily (Oct. 16, 2012) ? Cold viruses generally get a bad rap -- which they've certainly earned -- but new findings by a team of scientists at the Salk Institute for Biological Studies suggest that these viruses might also be a valuable ally in the fight against cancer.

Adenovirus, a type of cold virus, has developed molecular tools -- proteins -- that allow it to hijack a cell's molecular machinery, including large cellular machines involved in growth, replication and cancer suppression. The Salk scientists identified the construction of these molecular weapons and found that they bind together into long chains (polymers) to form a three-dimensional web inside cells that traps and overpowers cellular sentries involved in growth and cancer suppression. The findings, published Oct. 11 in Cell, suggest a new avenue for developing cancer therapies by mimicking the strategies employed by the viruses.

"Cancer was once a black box," says Clodagh O'Shea, an assistant professor in Salk's Molecular and Cell Biology Laboratory, who led the study. "The key that opened that box was revealing the interactions between small DNA tumor virus proteins and cellular tumor suppressor complexes. But without knowing the structure of the proteins they use to attack cells, we were at a loss for how these tiny weapons win out over much larger tumor suppressors."

O'Shea's team studied E4-ORF3, a cancer-causing protein encoded by adenovirus, which prevents the p53 tumor suppressor protein from binding to its target genes. Known as the "guardian of the genome," p53 normally suppresses tumors by causing cells with DNA damage -- a hallmark of cancer -- to self-destruct. The p53 tumor suppressor pathway is inactivated in almost every human cancer, allowing cancer cells to escape normal growth controls. Similarly, by inactivating p53, the E4-ORF3 protein enables adenovirus replication in infected human cells to go unchecked.

Two years ago, O'Shea discovered that E4-ORF3 clears the way for adenovirus to proliferate by deactivating genes that help the cell defend itself against the virus. "It literally creates zip files of p53 target genes by compressing them until they can no longer be read," she explains.

E4-ORF3 self-assembles inside cells into a disordered, web-like structure that captures and inactivates different tumor suppressor protein complexes. Horng Ou, a postdoctoral researcher in O'Shea's laboratory, says E4-ORF3 is unusual. "It doesn't resemble any known proteins that assemble polymers or that function in cellular tumor suppressor pathways," he says. "Most cellular polymers and filaments form uniform, rigid chains. But E4-ORF3 is the virus's Swiss army knife -- it assembles into something that is highly versatile. It has the ability to build itself into all sorts of different shapes and sizes that can capture and deactivate the many defenses of a host cell."

In collaboration with scientists from the National Center for Microscopy and Imaging Research at University of California, San Diego, led by Mark Ellisman, the center's director, O'Shea's team used new techniques to reveal the ultrastructure of the remarkable polymer that E4-ORF3 assembles in the nucleus -- something that previously had proven difficult since the polymer is effectively invisible using conventional electron microscopy. "What you see is the E4-ORF3 polymer bending and weaving and twisting its way through the nucleus," she says. "It does appear to have a single repeating pattern and creates a matrix that captures several different tumor suppressors and silences p53 target genes."

Initially, E4-ORF3 forms a dimer, made up of only two subunits. In this form, E4-ORF3 largely ignores its cellular targets. The researchers theorized that when E4-ORF3 assembles into a polymer, however, it binds to tumor suppressor targets far more aggressively. To test this theory, they genetically fused E4-ORF3 polymer mutants to lamin, a cellular protein that assembles intermediate filaments that provide stability and strength to cells. They showed that the lamin-E4-ORF3 fusion protein assembled into cylinder-like superstructures in the nucleus that bind and disrupt PML, a protein complex that suppresses tumors.

The Salk findings may help scientists develop small molecules -- the basis for the vast majority of current drugs -- capable of destroying tumors by binding and disrupting large and complex cellular components that allow cancer cells to grow and spread. Understanding how viruses overcome healthy cells may also help scientists engineer tumor-busting viruses, which offer a new and potentially self-perpetuating cancer therapy. Such modified viruses would destroy only cancer cells, because they could only replicate in cells in which the p53 tumor suppressor has been deactivated. When a cancer cell is destroyed it would release additional copies of the engineered viruses, which would seek out and kill remaining cancer cells that have spread throughout the body.

Engineering these viruses requires disabling the ability of the E4-ORF3 protein to inactivate p53 in healthy cells -- otherwise, the virus could destroy healthy cells as well as cancer cells. At the same time, E4-ORF3 has certain important functions in allowing the virus to replicate in the first place, so it can't be completely removed from the virus's arsenal. Thus, the Salk researcher's work on understanding the protein's precise structure, functions and interactions is crucial to engineering viruses in which E4-ORF3's abilities have been precisely modified.

Other researchers on the study were Witek Kwiatkowski, Katherine Blain, Hannah Land, Conrado Soria, Colin Powers, James Fitzpatrick, Jeff Long and Senyon Choe from the Salk Institute; Thomas Deerinck, Andrew Noske, Xiaokun Shu and Roger Tsien of the University of California, San Diego; and Andrew May of Fluidigm.

The work was supported by the National Institutes of Health, American Cancer Society, Sontag Foundation, the Arnold and Mabel Beckman Foundation, and Anna Fuller Foundation.

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Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Horng?D. Ou, Witek Kwiatkowski, Thomas?J. Deerinck, Andrew Noske, Katie?Y. Blain, Hannah?S. Land, Conrado Soria, Colin?J. Powers, Andrew?P. May, Xiaokun Shu, Roger?Y. Tsien, James?A.J. Fitzpatrick, Jeff?A. Long, Mark?H. Ellisman, Senyon Choe, Clodagh?C. O'Shea. A Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors. Cell, 2012; 151 (2): 304 DOI: 10.1016/j.cell.2012.08.035

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/0NNavMVNBB8/121016162830.htm

crimson tide

Filming Aboard a Transatlantic Military Medivac | Truly Free Film

By Matthew Heineman

One of the biggest surprises in our newly released documentary ?ESCAPE FIRE: The Fight to Rescue American Healthcare? is the storyline about how US military medicine is trying alternative treatments like yoga, meditation, and acupuncture for managing pain and reducing injured soldiers? reliance on addictive pharmaceutical drugs.

We follow a young combat veteran Sgt. Robert Yates, a self-professed ?hillbilly? who is addicted to painkillers after being injured in Afghanistan. He undergoes an amazing transformation over the course of the film by turning to these alternative treatments. As with the rest of America, treatment of pain and PTSD in injured soldiers is based almost entirely on throwing pills at the problems, which unfortunately often leads to addiction and even deadly overdoses or suicide.

The greatest challenge for my co-director Susan Froemke and me was getting access from the US military to film this compelling story. Not surprisingly, the Department of Defense is wary of cameras and filmmakers.

During our research stage, we found out about a novel clinical study to test whether administering acupuncture for pain relief could reduce drug use by injured soldiers on a military Medivac plane from the Army?s Landstuhl Regional Medical Center in Germany back to the US. We spent nearly a year trying to get permission to film aboard the plane. We were getting down to the wire. It was less than two weeks before the transatlantic flight, and we were nervous that we were going to miss the opportunity. Finally, just before Christmas in 2010, we got the final signoff from the US Army and the US Air Force, and I headed to Germany with our DP Wolfgang Held and soundman Peter Miller.

Shooting aboard the C-17 Air Force Medivac plane was definitely an exhilarating, moving experience. We got some of our most gripping footage on the flight and met Sgt. Yates just before we boarded the plane. During the flight, he was so heavily overmedicated with painkillers that he fell out of his cot?a dramatic moment we managed to capture on film (despite a public relations officer who tried to stop us by jumping in front of our camera).

Over the next few months, we gained Sgt. Yates? trust and followed him as he attempted to wean himself off a deadly cocktail of drugs through the help of an innovative program at Walter Reed Medical Center. We had to fight, negotiate, and plead to get permission to film there as well. But luckily we managed to do so and were able to shoot highly personal moments of Sgt. Yates during his transformation through low-cost, high-touch alternative approaches (meditation, acupuncture, therapy, etc.).

In the edit room, the story of Sgt. Yates? battle to recovery became the narrative backbone of the film. He?s one of those great verite characters documentary filmmakers pray for. His story began as a sad one, but through his courage and perseverance, he has inspired audiences all across the country. After countless screenings, we are still moved viscerally by him. And, ultimately, his story shows what happens when we open up our minds to something different?a lesson that we hope the US healthcare system can learn from.

?

Matthew Heineman is the director/producer (with Emmy Award-winner and Oscar Nominee Susan Froemke) of ESCAPE FIRE: The Fight to Rescue American Healthcare. The documentary, which is being released by Roadside Attractions/Lionsgate, is currently showing in select theatres, on iTunes, and via Video on Demand.

Source: http://trulyfreefilm.hopeforfilm.com/2012/10/filming-aboard-a-transatlantic-military-medivac.html

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Insurer UnitedHealth's 3Q profit jumps 23 percent

UnitedHealth Group's third-quarter net income jumped 23 percent, and the nation's largest health insurer raised its 2012 earnings forecast for the third time this year.

But company leaders also cautioned against thinking too positively about 2013. They said Tuesday that a stubbornly slow economy and the health care overhaul will combine to pressure the insurer's business again in the new year.

The Minnetonka, Minn., company now expects 2012 earnings of $5.20 to $5.25 per share, up from its previous forecast for $4.90 to $5 per share. Analysts expected $5.13 per share.

CEO Stephen J. Hemsley told analyst during a Tuesday conference call, the insurer expects growth in 2013 as well. But he said UnitedHealth must deal with tight government budgets that will squeeze its Medicare and Medicaid businesses and high unemployment rates that could hamper its private insurance enrollment.

The massive health care overhaul, which aims to cover millions of uninsured people, also will affect results next year. The law calls for a tax on premiums to start in 2014, but Hemsley said that will start to affect UnitedHealth's performance next year because the insurer will have to account for it in the rates it charges.

Insurers set their prices based on the claims or expenses they expect to have in future.

"We expect to grow revenues and earnings per share in 2013, but we view the current consensus level as a considerable challenge from this distance given these market conditions," he said.

Analysts expect, on average, earnings of $5.63 per share next year.

Hemsley also outlined concerns about the economy and employment levels last fall, as the insurer headed into 2012. UnitedHealth then went on to beat analyst expectations in every quarter so far this year. The CEO said Tuesday his company has successfully handled the broader market challenges it faces, but those obstacles still remain.

"We are actually in a good or better position than we were at this time last year," Hemsley said. "But we think we are being cautious, and we think the market should be cautious as well."

UnitedHealth Group Inc. will deliver its first 2013 earnings forecast next month at its annual investor meeting.

In the third quarter, the health benefits provider earned $1.56 billion, or $1.50 per share, overall. That compares with $1.27 billion, or $1.17 per share, in last year's third quarter.

Analysts had forecast earnings of $1.34 per share, and UnitedHealth said earlier this month its net income would be at least $1.45 per share.

Revenue rose 8 percent to $27.3 billion. That fell short of average analyst expectations of $27.58 billion, according to FactSet.

UnitedHealth said Tuesday its third quarter was helped by Medicare and retirement revenue that swelled by $1.2 billion, as Medicare Advantage enrollment grew by 400,000 people compared with last year.

Medicare Advantage plans are privately run, subsidized versions of the government's Medicare program for the elderly and disabled people. UnitedHealth is the largest provider of these plans, and it made a couple of acquisitions within the past year to help spur growth. Big health insurers have been snapping up smaller Medicare Advantage plan providers to prepare for the millions of Baby Boomers who will become eligible for this coverage over the next couple decades.

Aside from the Medicare growth, the insurer also recorded a $390 million benefit in the quarter because claims left over from earlier periods came in lower than expected, which freed up money held in reserve. That compares with a $200 million benefit in last year's quarter.

UnitedHealth is the first major insurer to report earnings every quarter, and Goldman Sachs analyst Matthew Borsch said in a Tuesday morning research note the report should set a positive tone for the sector, which also includes WellPoint Inc. and Aetna Inc.

But Borsch also said next month's presidential election will weigh more heavily on insurer stocks than earnings reports. He said a victory by Republican presidential candidate Mitt Romney will lead to a "strong and sustained" insurer rally. Romney has said he plans to repeal the health care overhaul if he's elected.

The overhaul is expected to add millions of new customers for insurers, but investors also are wary of the law's taxes and restrictions.

Shares of UnitedHealth, which became a Dow Jones industrial average component last month, fell 61 cents to close at $56.88 Tuesday.

Source: http://news.yahoo.com/insurer-unitedhealths-3q-profit-jumps-23-percent-102334184--finance.html

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Even Fox Is Calling Out Romney for Dishonesty | Alternet

?

For more than a month, Mitt Romney has cited six debunked studies to support his mathematically impossible plan to cut tax rates by 20 percent, while balancing the budget without raising taxes on the middle class. On Sunday, Fox News Sunday host Chris Wallace pressed senior Romney adviser Ed Gillespie on the credibility of these six studies, noting that each of them have serious issues:

GILLESPIE: Six different studies have said this is entirely doable.

WALLACE:?Those are very questionable. ?Some of them are blogs, some of them are from AEI, an independent group.

GILLESPIE: These are very credible sources.

WALLACE: One of them is a blog from a guy who was a top adviser for George W. Bush.? These are hardly non-partisan studies.

GILLESPIE: Look Chris these AEI and other studies are very credible sources of analysis

Watch it:

?

Two of the six studies are? Wall Street Journal editorials ?that repeat familiar Republican talking points without crunching any numbers. Wallace pointed out a third study from former Bush adviser Harvey Rosen, which assumes Romney?s plan would generate enough economic growth to? pay for the revenue loss , the same tax logic used by George W. Bush. Yet another one of the six studies is a white paper from the Romney campaign ?itself. Even an AEI tax expert suggested Romney?s math wouldn?t work , saying ?he?s going to need to cut rates significantly less than 20 percent if he wants to honor his other goals.?

But there is one study the Romney campaign hasn?t used. The Tax Policy Center found that Romney would need to? raise taxes on the middle class ?even if he closed every single tax loophole for the wealthy. Mark Zandi, chief economist of Moody?s Economy and an adviser to the 2008 McCain campaign, called that study the ? definitive? one on Romney?s plan

Source: http://www.alternet.org/news-amp-politics/even-fox-calling-out-romney-dishonesty

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No fear: Why teens are likelier to take gambles

Public release date: 15-Oct-2012
[ | E-mail | Share ]

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

A new study by Yale School of Medicine researchers and their colleagues finds that adolescents commonly take more risks than younger children and adults because they are more willing to accept risks when consequences are unknown, rather than because they are attracted to danger, as often assumed.

Adolescents have the highest rates of sexually transmitted diseases and criminal behaviors of any age group, and even drive faster than adults. The death and injury rate of adolescents is 200% greater than for their younger peers, according to research cited in the study.

Ifat Levy, assistant professor in comparative medicine and neurobiology at Yale, and colleagues report their results Oct. 1 in the Proceedings of the National Academies of Sciences. They explored risk-taking by studying a group of adolescents and a group of mid-life adults who were asked to make choices that involved known and unknown risks.

The 65 study participants, who ranged in age from 12 to 50, were asked to make a series of financial decisions in a lottery, each with varying degrees of risk. In some trials, subjects were told the exact probabilities of winning a lottery. In separate, ambiguous lotteries, they were not given the precise probabilities of winning, making the level of risk uncertain.

Levy and her team found that when risks were precisely stated, adolescents avoided them at least as much and sometimes more than adults. But adolescents were much more tolerant of ambiguity in situations where the likelihood of winning and losing was unknown. When the risk involved was not precisely known, they were more willing to accept them, compared to adults.

This makes sense biologically, Levy said. "Young organisms need to be open to the unknown in order to gain information about their world," she said. "From a policy perspective it means that informing adolescents as much as possible about the likelihoods for the costs and benefits of risky behaviors may effectively reduce their engagement in such behaviors."

Levy said it is not that adolescents lack the cognitive ability to understand their actionsadolescents are just as smart as adults. "Behavioral economics tells us that risk-taking is not a simple process," she said. "It is affected by our attitudes toward known risks, but also by our attitudes toward unknown or ambiguous situations, in which the likelihoods for positive and negative outcomes are not known."

###

Other authors on the study included Agnieszka Tymula, Lior Rosenberg Belmaker, Amy K. Roy, Lital Ruderman, Kirk Manson, and Paul W. Glimcher.

The research was supported by the National Institutes of Health, National Institute of Aging Grant.

Citation: www.pnas.org/cgi/doi/10.1073/pnas.1207144109

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 15-Oct-2012
[ | E-mail | Share ]

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

A new study by Yale School of Medicine researchers and their colleagues finds that adolescents commonly take more risks than younger children and adults because they are more willing to accept risks when consequences are unknown, rather than because they are attracted to danger, as often assumed.

Adolescents have the highest rates of sexually transmitted diseases and criminal behaviors of any age group, and even drive faster than adults. The death and injury rate of adolescents is 200% greater than for their younger peers, according to research cited in the study.

Ifat Levy, assistant professor in comparative medicine and neurobiology at Yale, and colleagues report their results Oct. 1 in the Proceedings of the National Academies of Sciences. They explored risk-taking by studying a group of adolescents and a group of mid-life adults who were asked to make choices that involved known and unknown risks.

The 65 study participants, who ranged in age from 12 to 50, were asked to make a series of financial decisions in a lottery, each with varying degrees of risk. In some trials, subjects were told the exact probabilities of winning a lottery. In separate, ambiguous lotteries, they were not given the precise probabilities of winning, making the level of risk uncertain.

Levy and her team found that when risks were precisely stated, adolescents avoided them at least as much and sometimes more than adults. But adolescents were much more tolerant of ambiguity in situations where the likelihood of winning and losing was unknown. When the risk involved was not precisely known, they were more willing to accept them, compared to adults.

This makes sense biologically, Levy said. "Young organisms need to be open to the unknown in order to gain information about their world," she said. "From a policy perspective it means that informing adolescents as much as possible about the likelihoods for the costs and benefits of risky behaviors may effectively reduce their engagement in such behaviors."

Levy said it is not that adolescents lack the cognitive ability to understand their actionsadolescents are just as smart as adults. "Behavioral economics tells us that risk-taking is not a simple process," she said. "It is affected by our attitudes toward known risks, but also by our attitudes toward unknown or ambiguous situations, in which the likelihoods for positive and negative outcomes are not known."

###

Other authors on the study included Agnieszka Tymula, Lior Rosenberg Belmaker, Amy K. Roy, Lital Ruderman, Kirk Manson, and Paul W. Glimcher.

The research was supported by the National Institutes of Health, National Institute of Aging Grant.

Citation: www.pnas.org/cgi/doi/10.1073/pnas.1207144109

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-10/yu-nfw101512.php

tony robbins

AAA: Utah gas prices drop slightly

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Video: Do you burn more calories sleeping or watching TV?

know is better nutrition. mmmm. great grains.

>>> today's healthy weight is brought to you by walmart. save money. live better. walmart.

>> and we are back with more of today on this winesday wednesday. ready to play who knew? in honor of nbc universal 's healthy week about to find out if you are in tip-top shape. kathie lee is at the nbc experience store, hand out $100 to those who get the answers right f they don't, a kathie lee cd. imagine that here is ms. madeleine turn strom , "today" diet and nutrition editor. are we ready? go ahead.

>> lovely lady from bridgeport, connecticut, true or false, you burn mor calories when you're asleep than when you're awake and watching tv ?

>> true. [ ding ]

>> really? 100 bucks. okay. tell us, tell us, how much do you burn?

>> you're going to burn twice as much when you're asleeps when watching tv , about 25 calories an hour watching tv .

>> why?

>> because sleep is actually active it is a state of active sleep. people thrash around. you know that feeling. so people -- you burn calories like that. twice as much when you are sleeping. don't call it couch potato for nothing.

>> back across to kath.

>> student on a school trip from roester, which of these foods has more calories, a chocolate frosted denut or a whole wheat bagel?

>> chocolate frosted doughnut?

>> thesere tricky. you got watch madeleine turn strom .

>> this seems czy, a bagel has more than a sweet doughnut.

>> the dough smut smaller, 270 calories, the bagel, bigger, bagels the size of your head, 350 calories without cream cheese or butter. up in are good choice. august about going smaller.

>> you can get the flagles.

>> she asked if she could look at the answer.

>> no. she is ao from rochester. okay. of the following four drinks, which has the most sugar? remember, madeleinesking this, mite maid cranberry grapes, coke, mountain due or snapple tea?

>> um, i'm going to go with mountain dew ? [ buzzer ]

>> oh. that's all right. everyone has a story.

>> you are fooling everyone. okay. so the juices are really packed with the calories.

>> 100% juice , juice full of sugar around the cran grape you eight-ounce serving, ten teaspoons of sugar. the soda and the snapple are mo party either,ix or seven teaspoons, all high in sugar park the juice is always going to have it don't be fool 13w50id 00% juice.

>> you water it down?

>> the best thing to do if you like real juice, water it down, half and half .

>> back across to kathy.

>> lady long way from home, roseville, california, welcome enough. eat two scoops of ice cream , about how long would you have to walk to burn off the calories? one hour, two hours, three hours or five hours. of course, it doesn't say what kind of ice cream . what do you think?

>> i'm going to say five hours? [ buzzer ]

>> and you would be wrong from roseville, california.

>> well. but hopefully --

>> okay. all right. so the correct answe here is two hours.

>> yeah. it is going to be two hours 'cause two scoops is about 300 each. taking a moderate walk, take you a couple hours to do that not a bad thing. if you want to enjoy it take that walk. remember, there's some payoff for eating that indulgence or have one scoop, only have to walk for an hour.

>> yeah. back across.

>> visiting from the beautiful town of chattanooga, we all want to satisfy our sweet tooth , especially hoda. of the following two items, which has less calories, nine hershey's kisses or one regular size nestle's crunch bar ?

>> a. nine hershey kisses . being ding ]

>> those are so good. and you get nine.

>> and you get nine of them. sometimes people think, that's so many, but a nestle's crunch, one big bar , 220, not a huge difference but nice to have nine to choose from. you know that serving, that's win.

>> madeleine turn strom , so are

Source: http://video.today.msnbc.msn.com/today/49359016/

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